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Description

Dubinski, A

The GH/IGF-1 axis in obesity: physiological and pathological aspects

As an analog of endogenous growth hormone-releasing hormone (GHRH), tesamorelin boasts a metabolism-stimulating activity that has led to its being approved as a treatment for lipodystrophy, or abnormal adipose fat accumulation associated with antiretroviral therapy for HIV.3 But this same activity can help non-HIV individuals shed abdominal fat of their own, while the peptides GHRH properties make it a suitable therapy for people looking to increase their lean mass

It is a synthetic 15-amino-acid peptide derived from a protein naturally found in human gastric juice

DNA fragments of ER-shRNA#30, ER-shRNA#98, SLC7A11-shRNA#3, SLC7A11-shRNA#24, SLC3A2-shRNA#86 and SLC3A2-shRNA#87 (sequences from Sigma-Aldrich website) were subcloned into the Eco R I and Age I digested pLKO.1 vector, respectively