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Beta-3 receptors are highly expressed in adipose tissue but have limited expression in most other tissues in adult humans

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In mouse studies, SLU-PP-332 has been characterized as an exercise mimetic compound: Increasing expression of PGC-1linked mitochondrial gene programs Raising resting energy expenditure and fat oxidation Reducing adiposity and improving glucose tolerance in diet-induced obese mice Boosting treadmill running capacity and endurance-type performance without requiring extra training Press coverage and preclinical papers describe SLU-PP-332 as making the body act like it is training for a marathon, even in sedentary animals, by shifting muscle toward more oxidative fiber types and denser mitochondria

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[2] [11] As of 2026, retatrutide has not received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA), and it remains an experimental compound available only within authorised clinical trial settings