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More critically, the generation of abundant autophagosomes significantly increases their fusion frequency with lysosomes, resulting in excessive burden and ultimate depletion of the lysosomal enzyme system whilst compromising lysosomal membrane structural integrity [87]

Air-dried rhizosphere soil samples were similarly analysed, but digested with 6 mL HNO 3 (70%) and 3 mL HCl (30%)

Stress, poor nutrition, and environmental pollutants can also deplete these levels

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Autophagy in a mouse model of distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy