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Gla residues are usually involved in binding calcium, and are essential for the biological activity of all known Gla proteins

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Scurvy is a complex disease involving several concomitant malfunctions, apparently all caused by the inactivation of different enzymes belonging to the large family of 2-oxoglutarate-dependent dioxygenases ( Table 1 )

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A large scale high-throughput screening of compounds with remyelinating effects identified a cluster of anti-muscarinic formulations, including clemastine, that enhance OPC differentiation and remyelination in vitro 43