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Compared with its homolog MFN2, MFN1 exhibits higher GTPase activity and relies more extensively on GTP hydrolysis to facilitate membrane fusion ( Under 4-HNEinduced lipid peroxidation, mitochondrial dynamics shift toward excessive fission

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doi: 10.1111/acer.12704 123

Chem Res Toxicol 30:1337 Faizan S, Mohsen MMA, Amarakanth C et al (2024) Quinone scaffolds as potential therapeutic anticancer agents: Chemistry, mechanism of Actions, Structure-Activity relationships and future perspectives

The high MOI ensures that the probability of having multiple cross-overs between copies of the infecting ssAdmid DNA is high