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Mutations and DNA damage may also be caused by oxidative changes to DNA sugar-phosphate backbones, which can be induced by O 2 - generating enzymes like NADPH oxidase and mitochondria

The Nrf2 protein, encoded by the NFE2L2 gene, regulates around 250 genes that play a role in maintaining cellular balance, including antioxidant proteins, detoxifying enzymes, drug transporters, and various cytoprotective proteins [43]

Mechanistically, BL-mediated protection involves downregulation of IFN- production, attenuation of cytotoxic microglial activation and CD4 + T cell responses, expansion of Treg populations, and suppression of Th17 cell differentiation

"Randomized clinical trial to comparing the efficacy of daily, weekly and monthly administration of vitamin D3"

10.1016/j.freeradbiomed.2008.12.018 243