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FIGURE 1 2.1.1 Iron chelators Deferoxamine (DFO) has been approved by the Food and Drug Administration (FDA) for subcutaneous injection to mitigate elastin-induced ferroptosis in an in vitro ferroptosis model ( DFO inhibits ferroptosis by chelating free intracellular Fe 3+ , down-regulating ROS, and up-regulating intracellular levels of GPX4, the ferritin heavy chain (FTH1), and Cystine/glutamic acid reverse transporter (System Xc-) (Zhang et al., 2020

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[3] Research has demonstrated that individuals with fatty liver disease frequently exhibit reduced hepatic glutathione levels

Jul/Aug 2019;27(4):202-207