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The occurrence of bone erosion during the progression of RA is closely related to the ROS-induced upregulation of nuclear factor of activated T cells 1 (NFATc1), a regulator of osteoclast activity and bone resorption in rats, which promotes RANKL-induced osteoclastogenesis and the differentiation of mouse bone marrow macrophages (BMMs) into osteoclasts

VLPs, which mimic the structure and properties of viral particles, have shown promise in cancer immunotherapy as antigen-presenting platforms or carriers of immunostimulatory molecules (Shahrivarkevishahi et al., 2022)