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In trials with semaglutide oral tablets, patients exposed to semaglutide 7 mg and 14 mg oral tablets had a mean increase from baseline in amylase of 10% and 13%, respectively, and lipase of 30% and 34%, respectively

Yes different mechanisms, no interaction concerns

Discussing alternative therapies or having regular nutrient IV therapy and/or vitamin B12 injections can help

The clinical presentation can be insidious, with symptoms developing so gradually that patients may not recognise the changes until deficiency becomes severe

However, in rare casessuch as patients with kidney disease or specific hereditary disorders related to vitamin B12 metabolismhigh doses or inappropriate use could potentially cause complications