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[452] In 2021, we launched Meaningful Measures 2.0 to promote innovation and modernization of all aspects of quality, and to address a wide variety of settings, stakeholders, and measure requirements

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It reduced pro-inflammatory cytokines, nitrate levels, and iNOS expression in the sciatic nerve, suggesting that bromelains antinociceptive and anxiolytic effects are linked to its ability to reduce inflammation [156]

However, these findings were not validated in animal models, and key pharmacological parametersincluding fertility outcomes, long-term toxicity, and pharmacokineticsremain uncharacterized

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