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Similar content being viewed by others Introduction Severe primary insulin-like growth factor-I (IGF-I Footnote 1 ) deficiency (SPIGFD) is a rare growth disorder which falls under the wider spectrum of IGF-I deficiency [1,2,3]

Additionally, SelS has been described as the regulator of the protein aggregation

Ethics declarations Competing interests PMC and EV are authors of the international patent WO2007090807 (Anti-met monoclonal antibody, fragments and vectors thereof ) owned by Metheresis Translational Research SA (Switzerland)

Therefore, after further investigation, that findings could aid in the exploration of new bioactive substances, introducing innovative perspectives to the medical and pharmaceutical fields