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Some closely match the doses and forms used in clinical research, while others fall short

The transfection efficiency was 70%

The predicted pathogenic variant D176Y has a damaging effecto on the binding with LC3B for the unphosphorylated forms of OPTN using the ensemble mode of MAVISp, i.e., which accounts for protein dynamics ( Figure 5F and Table 2 )

Although Treg cell depletion enhances tumor rejection, the ensuing autoimmune sequelae limits its utility in the clinic and highlights the need for limiting Treg cell activity within the tumor microenvironment