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It often starts in childhood and may continue as flare-ups in adulthood

However, this research is in its infancy, there are still plenty of challenges that need to be resolved, including long-term biosafety and the potential drug resistance, etc

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doi: 10.3389/fcell.2016.00016 Received 29 November 2015 Accepted 22 February 2016 Published 23 March 2016 Volume 4 - 2016 Edited by Gaetano Santulli, Columbia University in the City of New York, USA Reviewed by Yves Combarnous, Centre National de la Recherche Scientifique, France

10.1038/s41467-017-00498-4 127 LiuJ.CuiX.GuoF.LiX.LiL.PanJ.et al (2019)