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However, whether these changes occur in AH has not been elucidated

During aging, the activation of CD38 might increase NF-B signal transduction

Upadhyay et al., 2010b

doi: 10.2174/0115733998255538231001122639 2 HeatherLCGopalKSrnicNUssherJR

While this basic pH wash helps improve the stability of the antibodies later eluted with an acidic pH, its use as a wash step highlights the poor elution properties of a basic pH for many antibodies