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Research continues to examine its potential clinical applications, with studies investigating age-related changes in NAD+ levels and their possible associations with cellular functions1

Some evidence suggests that quiescent mHSCs favor anaerobic glycolysis over OXPHOS in hypoxia 36,37 , and that cytosolic redox shuttles (for example, malate-aspartate shuttle via MDH1/MDH2) help balance NADH to sustain both glycolysis and OXPHOS in mouse HSCs during self-renewal and in human glioblastoma stem cells 38,39 (Fig

doi: 10.1111/pbi.12020 53 GestN.GautierH.StevensR

doi: 10.1056/nejmoa2112651

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