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CD8 + T cells were activated and treated with ML226 for 11 days, as previously described, incubated at 21%, 5% or 1% oxygen for 2 h, and then reactivated with anti-CD3/CD28 Dynabeads

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Renal injury frequently causes endothelial dysfunction, characterized by altered vascular reactivity, increased permeability, and dysregulation of inflammatory and procoagulant pathways, thereby perpetuating hypoperfusion and contributing to maladaptive repair [43]