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For instance, the efficacy of combination relies on using strategies that normalize tumor vasculature and avoids detrimental vascular pruning as described above (144), most anti-angiogenic strategies are complicated by toxic sequelae due to their effects on normal tissues

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All patients were males, with a mean age of 52.8 years (DCM patients), 53.2 years (ICM patients), 52.6 years (HCM patients), and 51.6 years (controls)

Roesler R, Valvassori SS, Castro AA, Luft T, Schwartsmann G, Quevedo J