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They are members of the immunoglobulin superfamily and include 3 transmembrane proteins JAM-A, -B, and -C (also called JAM-1,2, and3) characterized by a short N-terminal portion, two extracellular immunoglobulin-like loops, a transmembrane portion, a short cytoplasm fragment containing phosphorylation sites and a C-terminal PDZ domain involved in cell-cell adhesion (67, 112)

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