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This is invasive and not always accessible, leading to severe diagnostic delays estimated to be between 4 to 11 years and a massive underestimation of disease prevalence

10.1073/pnas.1102281108 27 de SousaV

Fu X, Feng Y, Shao B, Zhang Y (2019) Activation of the ERK/Creb/Bcl2 pathway protects periodontal ligament stem cells against hydrogen peroxide-induced oxidative stress