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They can promote cell damage by increasing ROS (Silva et al., 2019)

Electroporation can improve the transdermal delivery of molecules with a size of at least 40 kDa, although permeability reduces with larger molecular sizes [163]

This procedure is based on methylene blue, first acting as a photosensitizer on preparative scale (1 mmol) in the initial singlet oxygen-mediated oxidation of 2-substituted furans and subsequently - upon dilution - acting as a redox catalyst during the formation of 5HP2Os on the AON (40 nmol scale)