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10.1186/2049-1891-4-52 5 AnC.ChonH.KuW.EomS.SeokM.KimS.et al (2022)

Persistent senescent cells can propagate the senescent phenotype, resulting in blood-brain barrier breakdown, infiltration of systemic immune cells, neurodegeneration, and gliosis, all of which are observed in the context of AD

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In addition, DHA induced ferroptosis as an antitumor agent in primary liver cancer (PLC) by activating the anti-survival unfolded protein response (UPR) and upregulating Chac GSH specific -glutamylcyclo-transferase 1 (CHAC1) expression, which was significantly attenuated by Fer-1 and DFO application after iron loading (95)