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Currently, the gene editing strategies for live bacteria mainly include CRISPR/Cas9 technology, zinc finger nuclease (ZFN) technology, and transcription activator-like effector nuclease (TALEN) technology

Thus, targeting NLRP3 inflammasome components may serve as a comprehensive unifying therapeutic approach to simultaneously inhibit or prevent multiple common aging diseases of the eye, while preserving the beneficial effects of VEGFA function

This typically lasts 5-15 minutes and is considered a normal physiological response rather than a concerning side effect

The aged HG cells can also be reactivated to regenerate upon the activation of mitophagy or GSH metabolism

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