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Key Points L-Arginine is the substrate of endothelial nitric oxide synthase and the main precursor of nitric oxide in the vascular endothelium Evidence indicates that intra-arterial or intravenous infusion of L-arginine rapidly improves nitric oxide bioavailability in the coronary arteries in both animal models and humans Oral treatment with L-arginine seems to improve endothelial function in high-risk patients, but this effect is not observed in healthy individuals, or in patients with coronary atherosclerosis or myocardial infarction who are receiving optimum medical treatment Although L-arginine is not associated with any serious adverse effects, there is still no conclusive evidence for its use for primary or secondary prevention of adverse cardiovascular events This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

10.4149/neo_2022_221007N992 121 MinY

Archived from the original on 6 October 2017

Supplementation of adult rats with moderate amounts of -carotene modulates the redox status in plasma without exerting pro-oxidant effects in the brain: A safer alternative to food fortification with vitamin A

Emerging nanotechnology platforms offer unprecedented precision in ferroptosis modulation