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While we dont understand how elevated IOP induces astrogliosis, physiological studies show a direct link between mechanical stress and astroglial [Ca2+]i (97)

For research teams studying anxiety without sedation, attention under stress, or cytokine modulation, the published evidence base is sufficient to plan a coherent study

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When cell number is increasing, it is referred to as hyperplasia, and when it increases in size, it is called hypertrophy (Muir et al., 2016

Accordingly, we have conducted longitudinal monitoring of GSH from various brain regions (frontal cortex (FC), parietal cortex (PC), occipital cortex (OC), and cerebellum (CER)) from healthy subjects using MEshcher-GArwood Point RESolved Spectroscopy (MEGA-PRESS) pulse sequence on a 3T scanner