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Patients had a mean age of 52 years (range: 26 to 79 years), 72% were male, 73% were White, 14% were Asian, 8% were American Indian/Alaska Native, and 5% were Black or African American

[129] [130] Later steps, especially the incorporation of the additional methyl groups of its structure, were investigated using 13 C methyl-labelled S-adenosyl methionine

The thus identified subjects were contacted by postal mail and invited to participate in the study

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