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doi: 10.4049/jimmunol.164.2.558 94 ParkJ

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Additionally, these reactive species induce DNA oxidation, leading to mitochondrial and nuclear DNA mutations, further impairing ATP production and exacerbating ETC dysfunction

Shao, H

Among the benefits for which L-theanine has been shown effective, youll find improvements in:4 Stress Sleep Neurological health (including memory and attention) Longevity Blood flow Theres also ample evidence that L-theanine can offset the less pleasant effects of caffeine and even work synergistically with caffeine to improve focus.14 15 Lets take a quick look at each of these potential benefits and what research says about them: Stress and anxiety In a Japanese study looking at the effects of 200mg of L-theanine, participants in the treatment groups verbal fluency and letter fluency improved in the face of stress compared to placebo.8 And a larger review of studies using 200-400mg doses found reductions in self-reported stress as well as improvements in stressor tasks, reaction time, and brain wave activity.16 Sleep L-Theanines sleep benefits are tied to its stress-reduction potential