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The standard Rituximab regimen includes two infusions of 1 g 2 weeks apart (some clinicians use 375 mg/m 2 weekly infusions for 4 weeks)

Ghoshal et al 266 reported that global genetic deficiency of COX-2 in mice resulted in a significant reduction in total body weight and body fat by attenuating PPAR ligand production and adipocyte differentiation

This reduction initiates intramolecular electron transfer, thereby enhancing the electronegativity of the relatively stable NO donor moiety within the molecule