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The Dual Agonist Breakthrough: Why Two Is Better Than One Tirzepatide, the first dual GLP-1/GIP agonist to reach market, demonstrated that activating both receptors produces superior results to activating GLP-1 alone

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Impaired renal function , an indicator of chronic kidney disease, also leads to higher serum MMA concentrations even from the early stages of renal impairment, as shown in (Figure 22b.6)

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