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Alterations in somatomedin can result in growth hormone deficiency with two known mechanisms

Ghanizadeh A, Mohammadi MR, Bahraini S, Keshavarzi Z, Firoozabadi A, Alavi, et al

Kearney, J

Its believed to promote musculoskeletal repair by upregulating growth factors, stimulating the formation of new blood vessels, or modulating nitric oxide synthesis, but no mechanism of action has been proven.34 TB4, however, has known mechanisms by which it speeds recovery from injury: inhibiting inflammation, preventing cell death, and (as suspected with BPC) promoting blood vessel formation.35 On top of the benefits for physical recovery, the ability to form new blood vessels points to promising implications for cardiovascular health

Chem Biol Interact 188(2):319333 Chauhan D, Kumar R