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Zhao C, Chen S, Chen D, Ro-Berg C, Zhang J, Van Der Wouden PE, et al

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the alpha2-mediated brimonidine effect leads to a reduction of intracellular cAMP production, the latter being responsible for NMDA activation in RGCs ( In vivo evidence confirmed that topical treatment with brimonidine decreased retinal damage induced by ocular hypertension and showed that analogous results were obtained by intraperitoneal administration of N-acetyl cysteine (Ozdemir et al., 2009)

She had a history of mixed-type irritable bowel syndrome and biliary colic but had never experienced rectal bleeding or hematochezia