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The observed depletion of carnosine likely reflects its rapid consumption due to redox imbalance in the inflamed lung, coupled with insufficient replenishment from remote synthesis sites (Figure 2H)

[Google Scholar] [PubMed] [CrossRef] Zhao HM, Xu R, Huang XY, Cheng SM, Huang MF, Yue HY, Wang X, Zou Y, Lu AP, Liu DY (2016)

Abbasi, S., Hosseini, F., Modabbernia, A., Ashrafi, M

The orally active PK activator mitapivat is the first approved therapeutic agent that is clinically beneficial for effective treatment of patients with PK deficiency (15, 16)