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Microglia also help remove brain toxins and cellular metabolic waste to maintain the homeostasis of the brain (Hasegawa-Ishii et al., 2011) and the degradation and morphological changes of microglial cells increased the risk of brain damage

16 , in some pathological conditions, such as ventilator-induced lung injury, the two TNF receptors can intercede contrasting effects after binding TNF-, with TNF Receptor 1 being damaging and TNF Receptor 2 slightly protective