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(-)-Guaiol inhibits tumor growth by inducing autophagy, inducing ICD, enhancing DC activation, and boosting T cell infiltration (267)

(i) the recent advancements in the use of I3C/DIM as therapeutic molecules since they represent potentially appealing anti-cancer agents, (ii) the available literature on the I3C and DIM characterization, and the challenges related to pharmacologic properties such as low solubility, and poor bioavailability, (iii) the synthesis and semi-synthetic derivatives, (iv) the mechanism of anti-tumor action in vitro/in vivo, (v) the action in cellular signaling pathways related to the regulation of apoptosis and anoikis as well as the cell cycle progression and cell proliferation such as peroxisome proliferator-activated receptor and PPAR agonists

It is known that cytokines play a key role in the pathogenesis of RA

van den Berg, A

Nat Rev Nephrol (2016) 12(2):6870