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This epigenetic silencing effectively inhibits class-switch DNA recombination (CSR), somatic hypermutation (SHM), and plasma cell differentiation, thereby reducing the production of both T-dependent and T-independent autoantibodies (e.g., anti-dsDNA antibodies)

Liu J, et al

Contrary to claudin-1, which in normal colonic epithelial cells is expressed to a minimum (even though it is highly increased in colon cancer tissue and cells 65 ), the claudin-7 protein is highly expressed in the colonic epithelium

Moreover, culture animals may be stressed by factors other than temperature and grow slower than expected for the culture system water temperature

Furthermore, obesity would lead to ventricular remodeling and dysfunction, which destroy the structure and physiological function of the heart, and eventually lead to heart failure (32)