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However, multiple factors during dialysis, such as poor biocompatibility, contaminated dialysis water, and immunosuppressive therapy, lead to proinflammatory and prooxidative effects that may adversely affect the aging process (Sturmlechner et al., 2017)

Randomized controlled trials (RCTs) report that IF reduces androgen markers, including total testosterone and free androgen index, in premenopausal females with obesity, while producing modest declines in testosterone among lean males without significantly affecting LH secretion [55]

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DOI: 10.1186/s40360-019-0296-8 PMID: 31077262 Burdick, A