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Upon HGF-induced activation of c-MET, phosphorylation at Y1003 recruits the E3 ubiquitin ligase CBL, leading to ubiquitination of c-MET

At doses of 1.0 and 5.0 ng/ml of rTGF 1, which are physiologically relevant levels in mice, 25 there were significant increases in BBB permeability (Figure 2b)

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