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The addition of Retatrutide, which improves insulin sensitivity through GLP-1 and GIP pathways, likely offsets any mild glucose-raising effect from Tesamorelin

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Furthermore, AI-driven drug repositioning based on pathway profiling revealed that Tanshinone IIA inhibits oxidative stress-induced hepatic fibrosis by stabilizing the "closed" conformation of Keap1 and enhancing its ubiquitinated degradation of Nrf2, a prediction validated by HDX-MS