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In the Calu3 LLI model, it has also been clearly demonstrated that the MC58 strain uses the transcellular route of infection (Sutherland et al., 2010)

166 When mtROS were depleted, NLRP3 inflammasome activation was inhibited

Indeed, biochemical control improved under modified release hydrocortisone [249], and recently published data from a 4-year longitudinal follow-up showed a minor increase in median HDL-C and unchanged TG levels in a cohort of patients shifting from conventional HC to modified release hydrocortisone and decreasing total daily dose from 30 to 20 mg/day [249, 250]

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Gluten-free diets, recommended for gluten sensitivity or celiac disease, altered gut microbiota profiles in healthy individuals, potentially affecting useful microbial species (McIntosh et al., 2016