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Taken together, glutamate-induced excitotoxicity may be a common process for neuronal death throughout the CNS and accelerates the original pathological changes

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To circumvent this problem, cell permeable probes were developed, in particular for sulfenic acids ( Statements Acknowledgments The work of Jean-Pierre Jacquot and Nicolas Rouhier was supported by grants from Institut Universitaire de France and the work of Jrmy Couturier and Nicolas Rouhier by ANR Grant No

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Periodic safety monitoring is required for these and certain other DMTs, including: Interferon (complete blood count [CBC] with differential and liver function every 3-6 months) S1P modulators (ocular examination whenever a change in vision is noted, CBC with differential every 3-6 months, periodic liver enzyme testing for fingolimod and if clinically indicated for other S1P modulators) Fumarates (CBC with differential and liver function testing every 3-6 months) Teriflunomide (CBC with differential every 3-6 months, liver function every month for first 6 months then every 3-6 months) Cladribine (age-appropriate cancer screenings, CBC with differential 2 and 6 months after starting each course