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White matter changes associated with antipsychotic treatment in first-episode psychosis

doi: 10.1016/j.apsoil.2012.02.009 140 MuhammadI.YangL.AhmadS.FarooqS

Without M6P modification, luminal enzymes, represented by CTSC and CTSD, cannot traffic to lysosomes and mature, resulting in a significant fraction being secreted into the media as unprocessed proenzymes (Fig