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Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

doi: 10.1038/nrc1586 35 MohmeMRiethdorfSPantelK

In addition, sleep deprivation increases growth hormone-releasing peptide levels and decreases LEP levels, which increases appetite and further contributes to obesity and chronic insomnia activates the hypothalamo-pituitary-adrenal axis, which increases stress hormones, exacerbates IR and promotes the development of MASLD (112,113)

This recognition encouraged preclinical studies aiming to investigate both mechanistic aspects and intervention strategies to characterize and target this biological axis in conditions affecting muscle, brain, the immune system, and metabolic diseases

10.1007/s11356-018-1521-5 35 KolarovaN.NapirkowskiP