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Ferrer-Luque et al., 2023)

Ritlecitinib was well tolerated in patients with AA according to an integrated safety analysis including four studies: 3 placebo-controlled (ALLEGRO phase 2a, pivotal ALLEGRO phase 2b/3, ALLEGRO phase 2a safety study) and 1 ongoing long-term open-label phase 3 study (ALLEGRO LT).26 Most AEs were mild, self-limited, and did not require treatment interruption or discontinuation

As a result, the tissues and organs don't get enough oxygen, which can cause a wide range of symptoms