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Acknowledgements This paper was supported by grants from the National Nature Scientific Foundation of China (No: 81770639), Construction project of advanced clinical medicine, Capital Medical University (No.1192070312) and Beijing Municipal Science & Technology Commission (No

Additionally, it was found that using a humanized monoclonal anti-VEGF antibody (Bevacizumab) was initially effective in decreasing tumor formation in Glioblastoma multiform (GBM) [106,107,108]