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Following dosing, the ARA 290 group increased their walk distance by a mean of 3.5% of baseline ( p = 0.09), whereas the placebo group increased walk distance by 1.1 % of baseline ( p = ns [not significant])

The CXCR4 receptor appears to be critically involved in many of these effects, particularly in regulating autophagy, IGF-1 abundance, Akt phosphorylation, and oxidative stress, as AMD3100 reversed these protective actions