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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

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These latter processes indicates that the metal ion is neurotoxic, and it has been associated to neurodegenerative diseases, such as the Alzheimer Disease 2 In this rather controversial context, the goal of chelation therapy is the removal of the toxic metal ion from the human body or the attenuation of its toxicity by transforming it into less toxic compounds