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Considering the role of environmental insults in the etiology and pathogenesis of ASD, these early investigations provide a basis for a broad and multifactorial analysis of potential individual root causes of ASD, and strategies for precision and personalized therapy

IHT, similarly to hypoxic pre- and postconditioning, can cause proadaptive modifications of the glucocorticoid system and stimulate production of the neurotrophins, in particular BDNF (Rybnikova et al., 2015) but to date no detailed studies have addressed these important aspects

Both can attenuate the negative effects of sleep deprivation (Wadhwa et al., 2015

Taken together, these studies revealed that metabolites can regulate both inflammatory and anti-inflammatory processes, in addition to intracellular metabolism and energetics

10.1021/acs.jctc.8b00933 48 HarrisonT.SamuelB