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RSL3 is known to interact with thioredoxin reductase 1 (Txnrd1) which also plays a role in DNA damage and oxidative stress 31

doi: 10.1038/s41598-017-10734-y 147 WanetA.ArnouldT.NajimiM.RenardP

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The reactive SH group of glutathione can form a thioether by reacting with C=C double bonds, carbonyl groups or other reactive groups forming a glutathione conjugate

A significant increase in hepatic STAT3 phosphorylation and acetylation and binding of FXR to Stat3 promoter, as well as decreased apoptosis markers by flow cytometry (FAS, caspase 8 and caspase 3), were present in FXR agonist/DDC mice compared to DDC mice