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It is administered through subcutaneous injection

TMAO is mostly excreted in the urine (Al-Waiz et al., 1987

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22Y11908100) Open Project of State Key Laboratory of Oncogenes and Related Genes (No.KF2120), YL Expert Workstation Project of Yunnan Province (No.202205AF150083), and the Innovative research team of high-level local universities in Shanghai

Access this article Similar content being viewed by others Abbreviations CAP: cyclic alternating pattern CBF: cerebral blood flow CSF: cerebrospinal fluid DA: dopamine DMN: default mode network DR: dorsal raphe EDS: excessive daytime sleepiness EEG: electroencephalogram GABA: gamma-aminobutyric acid GABA A -R: gamma-aminobutyric acid subtype A receptor GABA B -R: gamma-aminobutyric acid subtype B receptor GHB: gamma-hydroxybutyrate ICSD: International Classification of Sleep Disorders LC: locus coeruleus LDT: laterodorsal tegmental LST: long sleep time LXB: low-sodium oxybate MOA: mechanism of action MSLT: Multiple Sleep Latency Test N1, N2, N3, and N4: non-rapid eye movement sleep stages N1, N2, N3, and N4 NA: noradrenaline NREM: non-rapid eye movement NT1: narcolepsy type 1 NT2: narcolepsy type 2 PB: parabrachial PC: precoeruleus PPT: pedunculopontine tegmental PSG: polysomnography REM: rapid eye movement SE: sleep efficiency SWS: slow-wave sleep SXB: sodium oxybate TMN: tuberomammillary nucleus TST: total sleep time vPAG: ventral periaqueductal gray REFERENCES Stevens J, Schneider LD, Husain A, et al