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2023, 11.: 10.3390/diseases11020078 Karcioglu ZA: Zinc in the eye

Fibroblasts shape PDAC architecture

In the intrinsic pathway, attenuated Salmonella infection generates oxidative stress, which upregulates the pro-apoptotic Bax protein, downregulates the anti-apoptotic Bcl-2 protein, disrupts mitochondrial integrity, enhances cytochrome c release, and triggers caspase-9/3 cascade to induce apoptosis ( Salmonella can also modulate intracellular signaling pathways by inhibiting the pro-survival AKT/mTOR pathway and reducing NF-B activity to sensitize tumor cells to cell death and by activating the tumor suppressor p53 to enhance cell death signals ( Salmonella potently triggers apoptosis in tumor cells

3,3-Dichlorobenzidine is another aromatic amine associated with bladder cancer, primarily used in pigment and dye production, and has been shown to increase DNA damage risk in bladder epithelial cells (Ghosal and Iba, 1990

On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies