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The treatment is safe, minimally invasive, and well-tolerated

Yeast carboxypeptidase Y requires glycosylation for efficient intracellular transport, but not for vacuolar sorting, in vivo stability, or activity

Glutamine-derived -ketoglutarate (-KG) is an essential intermediate in the TCA cycle

Verma T, Bhardwaj S, Singh J, Kapoor D, Prasad R

A study assessing mutations and polymorphisms in patients with drug-induced cholestasis, disclosed that mutations in the ABCB11 gene was significantly more frequent in patients with drug-induced cholestasis compared to healthy controls [96]